Regular services go to Frankfurt, Cologne, Fulda, Limburg and from this cities your have extensive connections on the German high speed train network (ICE).
Wetzlar has no airport so head for Frankfurt/Main, Germany's busiest airport.
Wetzlar has a good connection to the German "Autobahn". Three junctions leads from the Autobahn 45 in the City. The federal route B49 beginns in Luxembourg and leads through the city.