The A9/E51 motorway passes west of Wittenberg. Use one of the exits Klein Marzehns, Köselitz or Coswig (Anhalt). The town lies at the crossing of the main roads B2 and B187.
Hourly ICE trains on the [wiki=4a887b8a68acf9b04d9d027bddedb06b]Leipzig[/wiki]-[wiki=ee1611b61f5688e70c12b40684dbb395]Berlin[/wiki] line stop in Wittenberg in both directions. The ride takes 40 minutes from Leipzig Hbf or 45 from Berlin Hbf. As a slower but cheaper option you can also use RE trains, which also run about hourly. The ride takes 1h15m from Berlin, 1h05m from Leipzig, or one hour from [wiki=d72261a58f8777c2da6598d43adbbf2b]Halle[/wiki].
Berlin Tegel , Berlin Schönefeld and Leipzig/Halle are the closest airports. Of these three, Berlin Tegel currently offers the widest range of international options.