There is a line from [wiki=980f6a55861604854079bbf295fa4784]San Benedetto del Tronto[/wiki] on the mainline along the Adriatic coast of Italy.
The station is few hundred meters outside the centre.
A bus from Rome begins this route from the street "Castro Pretorio", near Termini (the main train station of Rome)
and arrive in front of the train station, in Ascoli Piceno
http://www.startspa.it/navroma.htm
An easy alternate is the ROma MArche Linee, a direct bus line that leaves from Stazione Tiburtina and can drop you at any of the nearby coastal cities- San Benedetto del Tronto, Pedaso, Porto San Giorgo, Porto d'Ascoli, Cupra Marittima, and more. Scenic and enjoyable.
http://www.romamarchelinee.it/
From North, in the highway A14 the exit "Ascoli Piceno - San Benedetto del Tronto" than get the free highway "Ascoli-Mare" for 28Km following the indication
From Rome take the SS4 "Salaria" (Statal Street n°4) directed and passing to Rieti and after 197Km exit in "Rosara" and continue to East (on the left) for 2Km
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